Developmental Neurotoxicity Study of Dietary Bisphenol A in Sprague-Dawley Rats

AUTHOR
Donald Stump
PUBLICATION
Toxicological Sciences
DATE
January 22, 2010
FILED UNDER
health

The objective of this study, conducted in Sprague-Dawley rats, was to determine the potential of BPA to induce functional and/or morphological effects to the nervous system of offspring following dietary exposure of the mother during pregnancy and lactation. In this study, pregnant female rats were exposed to BPA via the diet at dosage levels that spanned the range from low doses, as used in some published studies reporting developmental neurotoxicity, to a high dose that was anticipated to result in systemic toxicity in the pregnant rat (0, 0.01, 0.1, 5, 50, and 150 mg/kg/day). 

The offspring, exposed to BPA in utero, via milk while nursing and through the diet once they started to feed, were studied for functional or morphological effects on their nervous systems. The study concluded that there were no neurologic or neurobehavioral effects at any dose tested.

At a Glance

What was tested?
Pregnant female rats were exposed to BPA via the diet at dosage levels that spanned the range from low doses, as used in some published studies reporting developmental neurotoxicity, to a high dose that was anticipated to result in systemic toxicity in the pregnant rat (0, 0.01, 0.1, 5, 50, and 150 mg/kg/day). The offspring, exposed to BPA in utero, via milk while nursing and through the diet once they started to feed, were studied for functional or morphological effects on their nervous systems.
Findings
Authors conculde that "...this DNT study clearly showed that there were no functional, sensory, or cognitive deficits resulting from BPA exposure during neurodevelopment, nor was there any evidence of effects on the ontogeny or motor activity. Brain weight, length and width, as well as histopathology and morphometry evaluations, also indicated no treatment-related effects on neurodevelopment. In addition, there were no developmental delays or evidence of effects on neurobehavioral development in this study."
Study Limitations
None cited
Importance
"Since BPA has weak estrogen-like properties, it has been hypothesized that BPA may affect neurodevelopment via an estrogenic mode of action." However, authors concluded that "Based on the conditions of this study, there was no evidence that BPA is a developmental neurotoxicant in rats."