BPA Safety Assessments & Studies - BPA Research

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Hundreds of laboratory studies on BPA have been conducted to better understand exposure and potential health effects. While the key BPA research studies summarized here are not intended to be exhaustive, these studies are significant because of their high utility for assessing the safety of BPA. Use the filters below to sort studies by topic focus or enter a specific search term.

exposure health
Evidence evaluated by European Food Safety Authority does not support lowering the temporary tolerable daily intake for bisphenol A

Date: January 23, 2024 | Authors: Robyn L Prueitt, Julie E Goodman from Gradient | Publication: Toxicological Sciences, Volume 198, Issue 2

The EFSA hazard assessment review process has led to a conclusion that there are low-dose effects of BPA based on very few, lower quality experimental animal studies. This conclusion is not supported by the totality of the available evidence, which inc …
exposure
Dietary Exposure – Food Packaging and Bisphenol A and Bis (2-Ethyhexyl) Phthalate Exposure: Findings from a Dietary Intervention

Date: March 30, 2011 | Authors: Rudel et al. | Publication: Environmental Health Perspectives

“BPA levels were more than 1,000 times below the government-established safe intake level.”
health
Comparison of lifestage-dependent internal dosimetry for bisphenol A, ethinyl estradiol, a reference estrogen, and endogenous estradiol to test an estrogenic mode of action in Sprague-Dawley rats

Date: January 2, 2014 | Authors: Churchwell et al | Publication: Publication

“The Churchwell study allows the Delclos results, in their entirety at low and high doses, to be more reliably interpreted…”
health
New FDA study finds no evidence of adverse health effects arising from low dose exposure to BPA

Date: February 4, 2014 | Authors: Delclos et al. | Publication: Toxicological Sciences

“Results demonstrated that no low dose effects were found for BPA in the wide range of health endpoints examined.”
exposure
Dietary Exposure – Daily Intake of Bisphenol A (BPA) and Potential Sources of Exposure – 2005-2006 National Health and Nutrition Examination Survey (NHANES)

Date: March 17, 2010 | Authors: LaKind and Naiman | Publication: Journal of Exposure Science & Environmental Epidemiology

“These levels are still almost 1,000 times below recommended safe exposure limits…”
metabolism
Metabolism in Monkeys – Pharmacokinetics of bisphenol A in neonatal and adult rhesus monkeys

Date: October 1, 2010 | Authors: Doerge et al. | Publication: Toxicology and Applied Pharmacology

“Any toxicological effect observed in rats from early postnatal exposures to BPA could over-predict those possible in primates of the same age…”
metabolism
Metabolism in Rats – Pharmacokinetics of bisphenol A in neonatal and adult Sprague-Dawley rats

Date: September 1, 2010 | Authors: Doerge et al. | Publication: Toxicology and Applied Pharmacology

“Studies that expose animals by subcutaneous injection are of limited relevance to human health concerns that primarily involve oral exposure…”
exposure metabolism
Metabolism in Humans – 24-Hour Human Urine and Serum Profiles of Bisphenol A During High Dietary Exposure

Date: June 24, 2011 | Authors: Teeguarden et al. (2011) | Publication: Toxicological Sciences

“This study confirmed that BPA is efficiently converted to a biologically inactive metabolite and rapidly excreted…”
exposure
Reproductive Health – Two-Generation Reproductive Toxicity Study of Dietary Bisphenol A in CD-1 (Swiss) Mice

Date: April 15, 2008 | Authors: Rochelle W. Tyl | Publication: Reproductive and Developmental Health

“BPA is not considered a selective reproductive or developmental toxicant…”
health
Reproductive Health – Basic Exploratory Research versus Guideline-Compliant Studies Used for Hazard Evaluation and Risk Assessment: Bisphenol A as a Case Study

Date: June 29, 2009 | Authors: Rochelle W. Tyl | Publication: Reproductive and Developmental Health

“Weight-of-evidence evaluations have consistently concluded that low-level BPA oral exposures do not adversely affect human developmental or reproductive health…”
exposure
Reproductive Behavior – In Utero and Lactational Exposure to Bisphenol A, In Contrast to Ethinyl Estradiol, Does Not Alter Sexually Dimorphic Behavior, Puberty, Fertility, and Anatomy of Female LE Rats

Date: October 15, 2009 | Authors: Bryce Ryan | Publication: Reproductive Development and Behavior

“No effects from exposure to BPA were found in this study.”
health
Developmental Neurotoxicity Study of Dietary Bisphenol A in Sprague-Dawley Rats

Date: January 22, 2010 | Authors: Donald Stump | Publication: Toxicological Sciences

“The study concluded that there were no neurologic or neurobehavioral effects at any dose tested.”