Reproductive Health - Two-Generation Reproductive Toxicity Study of Dietary Bisphenol A in CD-1 (Swiss) Mice

Author: Rochelle W. Tyl

Publication: Reproductive and Developmental Health

Date: April 15, 2008

exposure

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At a Glance

What was tested?
Twenty eight female mice per group were orally dosed with BPA starting before and throughout pregnancy and lactation at doses that spanned a range from low to very high. These adult females and two subsequent generations of their offspring, also dosed with BPA, were tested for reproductive and developmental health effects arising from exposure to BPA.
Findings
"BPA is not considered a selective reproductive or developmental toxicant in mice."
Study Limitations
Authors note that the species of mouse (CD-1 Swiss) used in this study had "not been a species of choice in guideline reproduction studies" due to some question about its sensitivity to estrogen, which could affect study results. To address this concern, researchers first tested the mouse species to assess sensitivity to estrogen and to establish a baseline for estrogen sensitivity upon which to measure and evaluate the BPA study results.
Importance
According to study authors, some research on BPA "has been criticized for lack of low doses, lack of and/or failure of positive controls, use of a less sensitive species and/or strain, inappropriate routes of exposure, and improper statistical analyses. These concerns have been addressed in the present study, which employed very low to very high dietary doses, an effective positive control, appropriate statistical analyses, an OECD Guideline protocol conducted under Organisation for Economic Cooperation and Development (OECD) Good Laboratory Practice (GLP) Principles, and used the CD-1 (Swiss) mouse."